Two battle-scarred, sleep-deprived GE-CIRT incident responders share lessons learned from the trenches, from their daily duties repelling real world, high-end network intrusions globally. This talk will include fresh thinking and innovative ideas in: intrusion response, intrusion detection, effective use of intel, and defensive operations. We will cover roughly a dozen (time permitting) cutting edge ideas and techniques that you can take back to your own organizations and put into practice right away.