Biological research is dominated by proprietary, black-box tools. This is hindering reproducibility, accountability and the advent of a more open scientific ecosystem. In this talk, we show the reverse engineering of two devices used in nearly every molecular biology experiment: a pipette and a -80ºC freezer. We show how reverse engineering these tools is not only fun, but necessary to enable open science. We will also put this work within the larger context of our effort to create open, interoperable data in biomedical research.
Charles Fracchia is the founder and CEO at BioBright, a company focusing on creating open, interoperable tools to revolutionize the process of biomedical research and provide a framework for more open science. He was recently named as one of 35 innovators under 35 by the Technology Review for his work tackling reproducibility in biomedical research. He is on a leave of absence from the MIT Media Lab where he was an IBM PhD Fellow in Joe Jacobson’s Molecular Machines group, and jointly in the Church lab at the Wyss Institute at Harvard Medical School. Charles is the recipient of several awards including IBM PhD fellowships, an Extraordinary Minds fellowship, one of the first Awesome Foundation fellowships and an Amplify Partners fellowship. He is the author of several patents and is actively authoring more in the field of future laboratory tools. Charles has also been involved in obtaining numerous grants and contracts from DARPA,NSF, Google X, Knight Foundation and the Shanghai High Tech Incubator totaling several millions since 2012. Charles has spoken about his work at many different venues and online including the White House, MIT Sloan, NASA Ames, IBM Research, Airbus, O'Reilly and HackADay. His current academic interests lie at the intersection of biological engineering and electronics called digital bioengineering. He was the Biology track chair at SOLID2015 mixing biology, electronics and computer science, instigated‡ and helped organize the Bits ↔ Bio conference, has represented Boston for the Hello Tomorrow challenge (European 100k), and is a founding member of the first US bio-hackerspace. Charles obtained his bachelor’s at Imperial College London, where he worked on a bioelectronic interface between engineered bacteria and electronic sensors. He continued his thesis work at IBM Research, where he has been encouraging research in the field ever since. Charles worked as an early intern at Ginkgo Bioworks, where he developed many of the automated assembly pipelines still used today.
Joel finished his bachelor's degree from Hampshire College in 2014, where he designed his own major, blending studies in cellular and molecular biology, neuroscience, and electrical and computer engineering. At Hampshire, Joel received the Ray and Lorna Coppinger Grant to lead a project developing an optogenetic interface for P19 differentiated neuronal cells. Later, while interning in the Robinson Neuroengineering Lab at Rice University, Joel worked to design and implement a novel platform to investigate single neuron computation using optogenetics and patch-clamp electrophysiology.